KRAS 8 Guhinduka

Guhindura ingingo muri gene ya KRAS byagaragaye mubwoko butandukanye bwibibyimba byabantu, hafi 17% ~ 25% ihinduka ryimiterere yibibyimba, 15% ~ 30% ihinduka ryimiterere yabarwayi ba kanseri yibihaha, 20% ~ 50% ihinduka rya kanseri yibara. abarwayi.Kuberako poroteyine ya P21 yashizwemo na gene ya K-ras iherereye hepfo yinzira yerekana inzira ya EGFR, nyuma ya mutation ya K-ras, inzira yerekana ibimenyetso byama nantaryo ikora kandi ntigire ingaruka kumiti yibasiwe na EGFR, bikavamo gukomeza ikwirakwizwa rya selile.Guhinduka kwa gene ya K-ras muri rusange bitanga imbaraga zo kurwanya EGFR tyrosine kinase inhibitor ku barwayi ba kanseri y'ibihaha no kurwanya imiti igabanya ubukana bwa EGFR ku barwayi ba kanseri yibara.Mu mwaka wa 2008, Ikigo cy’igihugu gishinzwe kurwanya kanseri (NCCN) cyasohoye umurongo ngenderwaho w’ubuvuzi bwa kanseri yibara, cyerekanaga ko ahantu hahindurwa mutation itera K-ras gukora cyane cyane muri kode ya 12 na 13 za exon 2, maze isaba ko abarwayi bose barwaye kanseri yu mura yateye imbere barashobora gupimwa ihinduka rya K-ras mbere yo kuvurwa.Kubwibyo, kumenya vuba na neza K-ras ihindagurika rya gene bifite akamaro kanini mubuyobozi bwo kuvura imiti.Iki gikoresho gikoresha ADN nk'icyitegererezo cyo gutahura kugira ngo gitange isuzuma ryujuje ubuziranenge bw'imiterere ya mutation, ishobora gufasha abaganga gusuzuma kanseri y'urura runini, kanseri y'ibihaha ndetse n'abandi barwayi b'ibibyimba bungukirwa n'ibiyobyabwenge.Ibisubizo by'ibizamini by'ibikoresho ni ibyavuzwe gusa kandi ntibigomba gukoreshwa nk'ishingiro ryonyine ryo kuvura abarwayi ku giti cyabo.Abaganga b’amavuriro bagomba gufata imyanzuro yuzuye kubisubizo by’ibizamini hashingiwe ku bintu nk’umurwayi umeze, ibimenyetso by’ibiyobyabwenge, igisubizo cy’ubuvuzi n’ibindi bipimo bya laboratoire.