Staphylococcus Aureus na Methicillin-Irwanya Staphylococcus Aureus Nucleic Acide

Staphylococcus aureus ni imwe muri bagiteri zikomeye zitera indwara ya nosocomial.Staphylococcus aureus (SA) ni iyitwa staphylococcus kandi ihagarariye bagiteri nziza ya Gram-positif, ishobora kubyara uburozi butandukanye hamwe na enzymes zitera.Indwara ya bagiteri ifite ibiranga gukwirakwiza kwinshi, gutera indwara zikomeye hamwe n’igipimo kinini cyo guhangana.Thermostable nuclease gene (nuc) ni gene yabitswe cyane ya staphylococcus aureus.Mu myaka yashize, kubera gukoresha cyane imisemburo no gutegura ubudahangarwa ndetse no gukoresha antibiyotike yagutse, kwandura nosocomial yatewe na Methicillin irwanya Staphylococcus aureus (MRSA) muri Staphylococcus.Ikigereranyo cy'igihugu cyo kumenya MRSA cyari 30.2% muri 2019 mu Bushinwa.MRSA igabanyijemo ibice bijyanye n'ubuvuzi MRSA (HA-MRSA), MRSA ifitanye isano n'abaturage (CA-MRSA), hamwe na MRSA ifitanye isano n'amatungo (LA-MRSA).CA-MRSA, HA-MRSA, LA-MRSA bafite itandukaniro rinini muri mikorobe, kurwanya bagiteri (urugero, HA-MRSA yerekana imiti myinshi irwanya CA-MRSA) nibiranga ivuriro (urugero aho banduye).Ukurikije ibyo biranga, CA-MRSA na HA-MRSA birashobora gutandukanywa.Ariko, itandukaniro riri hagati ya CA-MRSA na HA-MRSA riragabanuka kubera guhora kwimuka kwabantu hagati yibitaro nabaturage.MRSA irwanya ibiyobyabwenge byinshi, ntabwo irwanya antibiyotike ya β-lactam gusa, ahubwo irwanya aminoglycoside, macrolide, tetracycline na quinolone ku buryo butandukanye.Hariho itandukaniro rinini mu karere mubipimo byo kurwanya ibiyobyabwenge nuburyo butandukanye.

Methicillin irwanya mecA gene igira uruhare rukomeye mukurwanya staphylococcal.Gene ikorwa ku kintu cyihariye kigendanwa (SCCmec), igizwe na poroteyine 2a (PBP2a) ihuza penisiline kandi ikaba ifite aho ihuriye na antibiyotike ya β-lactam, ku buryo imiti igabanya ubukana idashobora kubangamira ikomatanyirizo ry’urukuta rwa peptidoglycan, bikaviramo kurwanya ibiyobyabwenge.