Umuntu ROS1 Fusion Gene Mutation

ROS1 ni transembrane tyrosine kinase yumuryango wa reseptor ya insuline.ROS1 fusion gene yemejwe nkindi gene yingenzi ya selile yibihaha ya kanseri y'ibihaha.Nkumuhagarariye ubwoko bushya bwa molekuline idasanzwe, kwandura gene ya ROS1 fusion muri NSCLC Hafi ya 1% kugeza 2% ROS1 ihura cyane na gene muri exons 32, 34, 35 na 36. Nyuma yo guhuzwa na gen nka CD74, EZR, SLC34A2, na SDC4, bizakomeza gukora akarere ka ROS1 tyrosine kinase.ROS1 kinase ikora idasanzwe irashobora gukora inzira yerekana ibimenyetso byerekana inzira nka RAS / MAPK / ERK, PI3K / Akt / mTOR, na JAK3 / STAT3, bityo ukagira uruhare mukwirakwiza, gutandukanya na metastasis ya selile yibibyimba, no gutera kanseri.Muri mutation ya ROS1, CD74-ROS1 igera kuri 42%, EZR igera kuri 15%, SLC34A2 igera kuri 12%, naho SDC4 igera kuri 7%.Ubushakashatsi bwerekanye ko urubuga rwa ATP ruhuza catalitiki ya ROS1 kinase hamwe na ATP-ihuza urubuga rwa ALK kinase ifite homologiya igera kuri 77%, bityo ALK tyrosine kinase ntoya ya molekile inhibitor crizotinib nibindi bigira ingaruka zigaragara zo gukiza mukuvura NSCLC hamwe na fusion mutation ya ROS1.Kubwibyo, kumenya ihinduka rya ROS1 fusion ni ishingiro nishingiro ryo kuyobora ikoreshwa ryibiyobyabwenge bya crizotinib.