Umuntu CYP2C9 na VKORC1 Gene Polymorphism

Warfarin ni anticoagulant yo mu kanwa ikunze gukoreshwa mubikorwa byubuvuzi muri iki gihe, igamije ahanini gukumira no kuvura indwara ziterwa na tromboembolique.Nyamara, warfarin ifite idirishya rito ryo kuvura kandi iratandukanye cyane mumoko atandukanye.Imibare yerekanye ko itandukaniro ryimiti ihamye mubantu batandukanye rishobora kuba inshuro zirenga 20.Amaraso mabi aturuka ku 15.2% by'abarwayi bafata warfarin buri mwaka, muri bo 3,5% bakagira amaraso yica.Ubushakashatsi bwa Pharmacogenomic bwerekanye ko polymorphism genetique ya enzyme yintego VKORC1 na enzyme ya metabolike CYP2C9 ya warfarin ari ikintu cyingenzi kigira ingaruka ku itandukaniro ryimiti ya warfarin.Warfarin ni ikintu cyihariye cya vitamine K epoxide reductase (VKORC1), bityo ikabuza guhuza ibintu byangiza umubiri birimo vitamine K kandi igatanga anticoagulation.Umubare munini wubushakashatsi wagaragaje ko gene polymorphism ya porotokoro ya VKORC1 aricyo kintu cyingenzi kigira ingaruka kumoko no gutandukana kwabantu kugipimo gikenewe cya warfarin.Warfarin ikoreshwa na CYP2C9, kandi ihinduka ryayo ritinda cyane metabolism ya warfarin.Abantu bakoresha warfarin bafite ibyago byinshi (inshuro ebyiri kugeza kuri eshatu hejuru) yo kuva amaraso mugihe cyambere cyo kuyakoresha.