Umuntu BCR-ABL Fusion Gene Mutation
Izina RY'IGICURUZWA
HWTS-GE010A-Umuntu BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Epidemiologiya
Indwara ya myelogenousleukemia idakira (CML) n'indwara mbi ya clone ya selile hematopoietic stem selile.Abarwayi ba CML barenga 95% batwara chromosome ya Philadelphia (Ph) mungirangingo zabo.Indwara yanduye ya CML niyi ikurikira: Gene fusion ya BCR-ABL ikorwa no guhinduranya hagati ya abl proto-oncogene (Abelson murine leukemia virusi oncogene homologi 1) ku kuboko kurekure kwa chromosome 9 (9q34) n'akarere ka cluster ( BCR) gene kumaboko maremare ya chromosome 22 (22q11);poroteyine ya fusion yashizwemo niyi gene ifite ibikorwa bya tyrosine kinase (TK), kandi ikora inzira yayo yerekana inzira yerekana inzira (nka RAS, PI3K, na JAK / STAT) kugirango iteze imbere amacakubiri no kubuza apoptose selile, bigatuma selile ziyongera nabi, bityo bigatera ibibaho bya CML.BCR-ABL ni kimwe mu bipimo byingenzi byo gusuzuma bya CML.Ihinduka ryinshi ryurwego rwinyandiko-mvugo ni ikimenyetso cyizewe cyo guca imanza za leukemia kandi zishobora gukoreshwa mu guhanura indwara ya leukemia nyuma yo kuvurwa.
Umuyoboro
| FAM | BCR-ABL fusion gene |
| VIC / HEX | Igenzura ryimbere |
Ibipimo bya tekiniki
| Ububiko | Amazi: ≤-18 ℃ Mu mwijima |
| Ubuzima bwa Shelf | Amazi: amezi 9 |
| Ubwoko bw'icyitegererezo | Ingero z'amagufwa |
| LoD | Amakopi 1000 / mL |
| Umwihariko
| Nta reaction-reaction hamwe nizindi genes zo guhuza TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, na PML-RARa |
| Ibikoresho bikoreshwa | Ikoreshwa rya Biosystems 7500 Sisitemu-Igihe nyacyo PCR Ikoreshwa rya Biosystems 7500 Byihuse-Igihe-Sisitemu ya PCR QuantStudio® 5 Sisitemu-Igihe Cyuzuye PCR SLAN-96P Sisitemu nyayo-PCR LightCycler®480 Sisitemu nyayo-PCR LineGene 9600 Yongeyeho Sisitemu-Igihe Cyuzuye PCR MA-6000-Igihe-Cyuzuye Cyumubare Wubushyuhe BioRad CFX96 Sisitemu-Igihe Cyuzuye PCR BioRad CFX Opus 96 Sisitemu Yigihe-PCR |
